HIV DNA-Adenovirus Multiclade Envelope Vaccine Induces gp41 Antibody Immunodominance in Rhesus Macaques

Dominant antibody responses in vaccinees who received the HIV-1 multiclade (A, B, and C) envelope (Env) DNA/recombinant adenovirus virus type 5 (rAd5) vaccine studied in HIV-1 Vaccine Trials Network (HVTN) efficacy trial 505 (HVTN 505) targeted Env gp41 and cross-reacted with microbial antigens. In...

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Bibliographic Details
Published in:J Virol
Main Authors: Han, Qifeng, Williams, Wilton B., Saunders, Kevin O., Seaton, Kelly E., Wiehe, Kevin J., Vandergrift, Nathan, Von Holle, Tarra A., Trama, Ashley M., Parks, Robert J., Luo, Kan, Gurley, Thaddeus C., Kepler, Thomas B., Marshall, Dawn J., Montefiori, David C., Sutherland, Laura L., Alam, Munir S., Whitesides, John F., Bowman, Cindy M., Permar, Sallie R., Graham, Barney S., Mascola, John R., Seed, Patrick C., Van Rompay, Koen K. A., Tomaras, Georgia D., Moody, M. Anthony, Haynes, Barton F.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2017
Subjects:
Vaccines and Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5640856/
https://ncbi.nlm.nih.gov/pubmed/28794027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00923-17
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