A Phase IIA Randomized Clinical Trial of a Multiclade HIV-1 DNA Prime Followed by a Multiclade rAd5 HIV-1 Vaccine Boost in Healthy Adults (HVTN204)

BACKGROUND: The safety and immunogenicity of a vaccine regimen consisting of a 6-plasmid HIV-1 DNA prime (envA, envB, envC, gagB, polB, nefB) boosted by a recombinant adenovirus serotype-5 (rAd5) HIV-1 with matching inserts was evaluated in HIV-seronegative participants from South Africa, United Sta...

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Detalhes bibliográficos
Main Authors: Churchyard, Gavin J., Morgan, Cecilia, Adams, Elizabeth, Hural, John, Graham, Barney S., Moodie, Zoe, Grove, Doug, Gray, Glenda, Bekker, Linda-Gail, McElrath, M. Juliana, Tomaras, Georgia D., Goepfert, Paul, Kalams, Spyros, Baden, Lindsey R., Lally, Michelle, Dolin, Raphael, Blattner, William, Kalichman, Artur, Figueroa, J. Peter, Pape, Jean, Schechter, Mauro, Defawe, Olivier, De Rosa, Stephen C., Montefiori, David C., Nabel, Gary J., Corey, Lawrence, Keefer, Michael C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3152265/
https://ncbi.nlm.nih.gov/pubmed/21857901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021225
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