Timing of Plasmid Cytokine (IL-2/Ig) Administration Affects HIV-1 Vaccine Immunogenicity in HIV-Seronegative Subjects

Background. To investigate the potential immunostimulatory effect of interleukin (IL) 2 as a human immunodeficiency virus type 1 (HIV-1) vaccine adjuvant, we conducted a study of a plasmid coding for a fusion protein of IL-2 and immunoglobulin (IL-2/Ig). Methods. This phase I trial evaluated an HIV-...

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Detalhes bibliográficos
Main Authors: Baden, Lindsey R., Blattner, William A., Morgan, Cecilia, Huang, Yunda, Defawe, Olivier D., Sobieszczyk, Magdalena E., Kochar, Nidhi, Tomaras, Georgia D., McElrath, M. Juliana, Russell, Nina, Brandariz, Kara, Cardinali, Massimo, Graham, Barney S., Barouch, Dan H., Dolin, Raphael
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3222108/
https://ncbi.nlm.nih.gov/pubmed/21940420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jir615
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