Timing of Plasmid Cytokine (IL-2/Ig) Administration Affects HIV-1 Vaccine Immunogenicity in HIV-Seronegative Subjects

Background. To investigate the potential immunostimulatory effect of interleukin (IL) 2 as a human immunodeficiency virus type 1 (HIV-1) vaccine adjuvant, we conducted a study of a plasmid coding for a fusion protein of IL-2 and immunoglobulin (IL-2/Ig). Methods. This phase I trial evaluated an HIV-...

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Bibliografiske detaljer
Main Authors: Baden, Lindsey R., Blattner, William A., Morgan, Cecilia, Huang, Yunda, Defawe, Olivier D., Sobieszczyk, Magdalena E., Kochar, Nidhi, Tomaras, Georgia D., McElrath, M. Juliana, Russell, Nina, Brandariz, Kara, Cardinali, Massimo, Graham, Barney S., Barouch, Dan H., Dolin, Raphael
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2011
Fag:
Major Articles and Brief Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3222108/
https://ncbi.nlm.nih.gov/pubmed/21940420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jir615
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