Safety and Immunogenicity of a Recombinant Adenovirus Serotype 35-Vectored HIV-1 Vaccine in Adenovirus Serotype 5 Seronegative and Seropositive Individuals

BACKGROUND: Recombinant adenovirus serotype 5 (rAd5)-vectored HIV-1 vaccines have not prevented HIV-1 infection or disease and pre-existing Ad5 neutralizing antibodies may limit the clinical utility of Ad5 vectors globally. Using a rare Ad serotype vector, such as Ad35, may circumvent these issues,...

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Bibliografiske detaljer
Udgivet i:J AIDS Clin Res
Main Authors: Fuchs, Jonathan D, Bart, Pierre-Alexandre, Frahm, Nicole, Morgan, Cecilia, Gilbert, Peter B, Kochar, Nidhi, DeRosa, Stephen C, Tomaras, Georgia D, Wagner, Theresa M, Baden, Lindsey R, Koblin, Beryl A, Rouphael, Nadine G, Kalams, Spyros A, Keefer, Michael C, Goepfert, Paul A, Sobieszczyk, Magdalena E, Mayer, Kenneth H, Swann, Edith, Liao, Hua-Xin, Haynes, Barton F, Graham, Barney S, McElrath, M Juliana
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4648371/
https://ncbi.nlm.nih.gov/pubmed/26587311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4172/2155-6113.1000461
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