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DNA Methyltransferases Demonstrate Reduced Activity Against Arabinosylcytosine: Implications for Epigenetic Instability in AML
Arabinosylcytosine (araC) is a mainstay in the initial treatment of acute myeloid leukemia (AML), although relapses are common. Given recent recognition of altered DNA methylation patterns in relapsed AML, we considered whether araC, which acts by incorporation into DNA, could itself perturb methyla...
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| Publicado no: | Biochemistry |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5638661/ https://ncbi.nlm.nih.gov/pubmed/28394581 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b00208 |
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