Genomic and chromatin features shaping meiotic double-strand break formation and repair in mice

The SPO11-generated DNA double-strand breaks (DSBs) that initiate meiotic recombination occur non-randomly across genomes, but mechanisms shaping their distribution and repair remain incompletely understood. Here, we expand on recent studies of nucleotide-resolution DSB maps in mouse spermatocytes....

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Bibliographic Details
Published in:Cell Cycle
Main Authors: Yamada, Shintaro, Kim, Seoyoung, Tischfield, Sam E., Jasin, Maria, Lange, Julian, Keeney, Scott
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5638367/
https://ncbi.nlm.nih.gov/pubmed/28820351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2017.1361065
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