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Control of meiotic double-strand-break formation by ATM: local and global views

DNA double-strand breaks (DSBs) generated by the SPO11 protein initiate meiotic recombination, an essential process for successful chromosome segregation during gametogenesis. The activity of SPO11 is controlled by multiple factors and regulatory mechanisms, such that the number of DSBs is limited a...

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Detalhes bibliográficos
Publicado no:Cell Cycle
Main Authors: Lukaszewicz, Agnieszka, Lange, Julian, Keeney, Scott, Jasin, Maria
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6110601/
https://ncbi.nlm.nih.gov/pubmed/29963942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2018.1464847
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