The landscape of mouse meiotic double-strand break formation, processing and repair

Heritability and genome stability are shaped by meiotic recombination, which is initiated via hundreds of DNA double-strand breaks (DSBs). The distribution of DSBs throughout the genome is not random, but mechanisms molding this landscape remain poorly understood. Here we exploit genome-wide maps of...

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Veröffentlicht in:Cell
Hauptverfasser: Lange, Julian, Yamada, Shintaro, Tischfield, Sam E., Pan, Jing, Kim, Seoyoung, Zhu, Xuan, Socci, Nicholas D., Jasin, Maria, Keeney, Scott
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5117687/
https://ncbi.nlm.nih.gov/pubmed/27745971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.09.035
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