The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells

Obesity and elevated circulating cholesterol are risk factors for breast cancer recurrence, while the use of statins, cholesterol biosynthesis inhibitors widely used for treating hypercholesterolemia, is associated with improved disease-free survival. Here, we show that cholesterol mediates the meta...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Baek, Amy E., Yu, Yen-Rei A., He, Sisi, Wardell, Suzanne E., Chang, Ching-Yi, Kwon, Sanghoon, Pillai, Ruchita V., McDowell, Hannah B., Thompson, J. Will, Dubois, Laura G., Sullivan, Patrick M., Kemper, Jongsook K., Gunn, Michael D., McDonnell, Donald P., Nelson, Erik R.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5636879/
https://ncbi.nlm.nih.gov/pubmed/29021522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00910-z
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