The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells

Obesity and elevated circulating cholesterol are risk factors for breast cancer recurrence, while the use of statins, cholesterol biosynthesis inhibitors widely used for treating hypercholesterolemia, is associated with improved disease-free survival. Here, we show that cholesterol mediates the meta...

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Publicado en:Nat Commun
Autores principales: Baek, Amy E., Yu, Yen-Rei A., He, Sisi, Wardell, Suzanne E., Chang, Ching-Yi, Kwon, Sanghoon, Pillai, Ruchita V., McDowell, Hannah B., Thompson, J. Will, Dubois, Laura G., Sullivan, Patrick M., Kemper, Jongsook K., Gunn, Michael D., McDonnell, Donald P., Nelson, Erik R.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5636879/
https://ncbi.nlm.nih.gov/pubmed/29021522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00910-z
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