Induced sensitivity to EGFR inhibitors is mediated by palmitoylated cysteine 1025 of EGFR and requires oncogenic Kras

Currently, there are no effective therapeutic strategies targeting Kras driven cancers, and therefore, identifying new targeted therapies and overcoming drug resistance have become paramount for effective long-term cancer therapy. We have found that reducing expression of the palmitoyl transferase D...

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Vydáno v:Biochem Biophys Res Commun
Hlavní autoři: Kharbanda, Akriti, Runkle, Kristin, Wang, Wei, Witze, Eric S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5636688/
https://ncbi.nlm.nih.gov/pubmed/28899783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2017.09.044
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