Unfolded protein response transducer IRE1-mediated signaling independent of XBP1 mRNA splicing is not required for growth and development of medaka fish

When activated by the accumulation of unfolded proteins in the endoplasmic reticulum, metazoan IRE1, the most evolutionarily conserved unfolded protein response (UPR) transducer, initiates unconventional splicing of XBP1 mRNA. Unspliced and spliced mRNA are translated to produce pXBP1(U) and pXBP1(S...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Ishikawa, Tokiro, Kashima, Makoto, Nagano, Atsushi J, Ishikawa-Fujiwara, Tomoko, Kamei, Yasuhiro, Todo, Takeshi, Mori, Kazutoshi
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5636610/
https://ncbi.nlm.nih.gov/pubmed/28952924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.26845
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