Unfolded protein response transducer IRE1-mediated signaling independent of XBP1 mRNA splicing is not required for growth and development of medaka fish

When activated by the accumulation of unfolded proteins in the endoplasmic reticulum, metazoan IRE1, the most evolutionarily conserved unfolded protein response (UPR) transducer, initiates unconventional splicing of XBP1 mRNA. Unspliced and spliced mRNA are translated to produce pXBP1(U) and pXBP1(S...

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Vydáno v:eLife
Hlavní autoři: Ishikawa, Tokiro, Kashima, Makoto, Nagano, Atsushi J, Ishikawa-Fujiwara, Tomoko, Kamei, Yasuhiro, Todo, Takeshi, Mori, Kazutoshi
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2017
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5636610/
https://ncbi.nlm.nih.gov/pubmed/28952924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.26845
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