Public antibodies to malaria antigens generated by two LAIR1 insertion modalities

We previously described two donors in whom the extracellular domain of LAIR1, a collagen-binding inhibitory receptor encoded on chromosome 191, was inserted between the V and the DJ segments of an antibody. This insertion generated, through somatic mutations, broadly reactive antibodies against RIFI...

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Veröffentlicht in:Nature
Hauptverfasser: Pieper, Kathrin, Tan, Joshua, Piccoli, Luca, Foglierini, Mathilde, Barbieri, Sonia, Chen, Yiwei, Silacci-Fregni, Chiara, Wolf, Tobias, Jarrossay, David, Anderle, Marica, Abdi, Abdirahman, Ndungu, Francis M., Doumbo, Ogobara K., Traore, Boubacar, Tran, Tuan M., Jongo, Said, Zenklusen, Isabelle, Crompton, Peter D., Daubenberger, Claudia, Bull, Peter C., Sallusto, Federica, Lanzavecchia, Antonio
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5635981/
https://ncbi.nlm.nih.gov/pubmed/28847005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature23670
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