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Evolutionary diversification of protein–protein interactions by interface add-ons

Cells contain a multitude of protein complexes whose subunits interact with high specificity. However, the number of different protein folds and interface geometries found in nature is limited. This raises the question of how protein–protein interaction specificity is achieved on the structural leve...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Plach, Maximilian G., Semmelmann, Florian, Busch, Florian, Busch, Markus, Heizinger, Leonhard, Wysocki, Vicki H., Merkl, Rainer, Sterner, Reinhard
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2017
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5635890/
https://ncbi.nlm.nih.gov/pubmed/28923934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1707335114
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