Evolutionary diversification of protein–protein interactions by interface add-ons

Cells contain a multitude of protein complexes whose subunits interact with high specificity. However, the number of different protein folds and interface geometries found in nature is limited. This raises the question of how protein–protein interaction specificity is achieved on the structural leve...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Plach, Maximilian G., Semmelmann, Florian, Busch, Florian, Busch, Markus, Heizinger, Leonhard, Wysocki, Vicki H., Merkl, Rainer, Sterner, Reinhard
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2017
Teme:
PNAS Plus
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5635890/
https://ncbi.nlm.nih.gov/pubmed/28923934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1707335114
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