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Divergent unprotected peptide macrocyclisation by palladium-mediated cysteine arylation
Macrocyclic peptides are important therapeutic candidates due to their improved physicochemical properties in comparison to their linear counterparts. Here we detail a method for a divergent macrocyclisation of unprotected peptides by crosslinking two cysteine residues with bis-palladium organometal...
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| Pubblicato in: | Chem Sci |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Royal Society of Chemistry
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5635729/ https://ncbi.nlm.nih.gov/pubmed/29081961 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6sc05454d |
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