Divergent unprotected peptide macrocyclisation by palladium-mediated cysteine arylation

Macrocyclic peptides are important therapeutic candidates due to their improved physicochemical properties in comparison to their linear counterparts. Here we detail a method for a divergent macrocyclisation of unprotected peptides by crosslinking two cysteine residues with bis-palladium organometal...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Chem Sci
Prif Awduron: Rojas, Anthony J., Zhang, Chi, Vinogradova, Ekaterina V., Buchwald, Nathan H., Reilly, John, Pentelute, Bradley L., Buchwald, Stephen L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Royal Society of Chemistry 2017
Pynciau:
Chemistry
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5635729/
https://ncbi.nlm.nih.gov/pubmed/29081961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6sc05454d
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg