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An Umpolung Approach for the Chemoselective Arylation of Selenocysteine in Unprotected Peptides

[Image: see text] Herein we report an umpolung strategy for the bioconjugation of selenocysteine in unprotected peptides. This mild and operationally simple approach takes advantage of the electrophilic character of an oxidized selenocysteine (Se–S bond) to react with a nucleophilic arylboronic acid...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Cohen, Daniel T., Zhang, Chi, Pentelute, Bradley L., Buchwald, Stephen L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2015
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4613869/
https://ncbi.nlm.nih.gov/pubmed/26225900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b05447
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