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Nitrogen Arylation for Macrocyclization of Unprotected Peptides
We describe an efficient and mild method for the synthesis of macrocyclic peptides via nitrogen arylation from unprotected precursors. Various electro-philes and lysine-based nucleophiles were investigated and showed high-yielding product formation, even for a macrocyclization scan with 14 variants....
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| 出版年: | J Am Chem Soc |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6150454/ https://ncbi.nlm.nih.gov/pubmed/27332147 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b03757 |
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