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An Umpolung Approach for the Chemoselective Arylation of Selenocysteine in Unprotected Peptides

[Image: see text] Herein we report an umpolung strategy for the bioconjugation of selenocysteine in unprotected peptides. This mild and operationally simple approach takes advantage of the electrophilic character of an oxidized selenocysteine (Se–S bond) to react with a nucleophilic arylboronic acid...

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Publicado en:J Am Chem Soc
Main Authors: Cohen, Daniel T., Zhang, Chi, Pentelute, Bradley L., Buchwald, Stephen L.
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2015
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4613869/
https://ncbi.nlm.nih.gov/pubmed/26225900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b05447
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