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Water-Soluble Palladium Reagents for Cysteine S-Arylation under Ambient Aqueous Conditions

We report the use of a sulfonated biarylphosphine ligand (sSPhos) to promote the chemoselective modification of cysteine containing proteins and peptides with palladium reagents in aqueous medium. The use of sSPhos allowed for the isolation of several air-stable and water-soluble mono- and bis-palla...

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Publicado en:Org Lett
Main Authors: Rojas, Anthony J., Pentelute, Bradley L., Buchwald, Stephen L.
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5818991/
https://ncbi.nlm.nih.gov/pubmed/28777001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.7b01911
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