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Organometallic Gold(III) Reagents for Cysteine Arylation

An efficient method for chemoselective cysteine arylation of unprotected peptides and proteins using Au(III) or- ganometallic complexes is reported. The bioconjugation reactions proceed rapidly (<5 min) at ambient temperature in various buffers and within a wide pH range (0.5–14). This approach p...

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Détails bibliographiques
Publié dans:J Am Chem Soc
Auteurs principaux: Messina, Marco S., Stauber, Julia M., Waddington, Mary A., Rheingold, Arnold L., Maynard, Heather D., Spokoyny, Alexander M.
Format: Artigo
Langue:Inglês
Publié: 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6491213/
https://ncbi.nlm.nih.gov/pubmed/29790740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b04115
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