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Structural basis for IL-1α recognition by a modified DNA aptamer that specifically inhibits IL-1α signaling
IL-1α is an essential cytokine that contributes to inflammatory responses and is implicated in various forms of pathogenesis and cancer. Here we report a naphthyl modified DNA aptamer that specifically binds IL-1α and inhibits its signaling pathway. By solving the crystal structure of the IL-1α/apta...
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| Publicado en: | Nat Commun |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5634487/ https://ncbi.nlm.nih.gov/pubmed/28993621 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00864-2 |
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