Inflammatory activation of human cardiac fibroblasts leads to altered calcium signaling, decreased connexin 43 expression and increased glutamate secretion

Cardiac fibroblasts, which are abundant in heart tissue, are involved not only in extracellular matrix homeostasis and repair, but also in cardiac remodeling after a myocardial infarction that, in turn, can lead to loss of cardiac function and heart failure. Ca(2+) signaling is functionally importan...

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Veröffentlicht in:Heliyon
Hauptverfasser: Skiöldebrand, Eva, Lundqvist, Annika, Björklund, Ulrika, Sandstedt, Mikael, Lindahl, Anders, Hansson, Elisabeth, Hultén, Lillemor Mattsson
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5633159/
https://ncbi.nlm.nih.gov/pubmed/29022008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.heliyon.2017.e00406
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