Hypoxic cardiac fibroblasts from failing human hearts decrease cardiomyocyte beating frequency in an ALOX15 dependent manner

A common denominator for patients with heart failure is the correlation between elevated serum levels of proinflammatory cytokines and adverse clinical outcomes. Furthermore, lipoxygenase-induced inflammation is reportedly involved in the pathology of heart failure. Cardiac fibroblasts, which are ab...

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Veröffentlicht in:PLoS One
Hauptverfasser: Sandstedt, Mikael, Rotter Sopasakis, Victoria, Lundqvist, Annika, Vukusic, Kristina, Oldfors, Anders, Dellgren, Göran, Sandstedt, Joakim, Hultén, Lillemor Mattsson
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6107211/
https://ncbi.nlm.nih.gov/pubmed/30138423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0202693
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