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Fosfomycin (FOS) Plus Meropenem (MER) Suppresses Resistance Emergence Against P. aeruginosa (PA) PAO1 in the Hollow Fiber Infection Model (HFIM)

BACKGROUND: FOS (ZTI-01, fosfomycin for injection) is an epoxide antibiotic that covalently binds MurA, an earlier step in cell wall synthesis inhibition. FOS has demonstrated synergistic killing with other classes of agents, including carbapenems. PA, among other non-fermentors, are difficult to tr...

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Bibliografski detalji
Izdano u:Open Forum Infect Dis
Glavni autori: Louie, Arnold, Maynard, Michael, Duncanson, Brandon, Vicchiarelli, Michael, Drusano, George L
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5630751/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofx163.1219
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