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Polymyxin B Pharmacodynamics in the Hollow-Fiber Infection Model: What You See May Not Be What You Get
Dose range studies for polymyxin B (PMB) regimens of 0.75 to 12 mg/kg given every 12 h (q12h) were evaluated for bacterial killing and resistance prevention against an AmpC-overexpressing Pseudomonas aeruginosa and a bla(KPC-3)-harboring Klebsiella pneumoniae in 10-day in vitro hollow-fiber models....
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| Udgivet i: | Antimicrob Agents Chemother |
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| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Microbiology
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8284464/ https://ncbi.nlm.nih.gov/pubmed/34097487 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01853-20 |
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