Linezolid Kills Acid-Phase and Nonreplicative-Persister-Phase Mycobacterium tuberculosis in a Hollow-Fiber Infection Model

The therapy for treatment of Mycobacterium tuberculosis infections is long and arduous. It has been hypothesized that the therapy duration is driven primarily by populations of organisms in different metabolic states that replicate slowly or not at all (acid-phase and nonreplicative-persister [NRP]-...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Drusano, G. L., Myrick, Jenny, Maynard, Michael, Nole, Jocelyn, Duncanson, Brandon, Brown, David, Schmidt, Stephan, Neely, Michael, Scanga, C. A., Peloquin, Charles, Louie, Arnold
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6105790/
https://ncbi.nlm.nih.gov/pubmed/29866864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00221-18
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