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Fosfomycin (FOS) Plus Meropenem (MER) Suppresses Resistance Emergence Against P. aeruginosa (PA) PAO1 in the Hollow Fiber Infection Model (HFIM)
BACKGROUND: FOS (ZTI-01, fosfomycin for injection) is an epoxide antibiotic that covalently binds MurA, an earlier step in cell wall synthesis inhibition. FOS has demonstrated synergistic killing with other classes of agents, including carbapenems. PA, among other non-fermentors, are difficult to tr...
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| Udgivet i: | Open Forum Infect Dis |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5630751/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofx163.1219 |
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