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Differing Effects of Combination Chemotherapy with Meropenem and Tobramycin on Cell Kill and Suppression of Resistance of Wild-Type Pseudomonas aeruginosa PAO1 and Its Isogenic MexAB Efflux Pump-Overexpressed Mutant

The drug interaction terminology (synergy, additivity, antagonism) relates to bacterial kill. The suppression of resistance requires greater drug exposure. We examined the combination of meropenem and tobramycin for kill and resistance suppression (wild-type Pseudomonas aeruginosa PAO1 and its isoge...

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Bibliografische gegevens
Hoofdauteurs: Drusano, G. L., Liu, Weiguo, Fregeau, Christine, Kulawy, Robert, Louie, Arnold
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology (ASM) 2009
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2687233/
https://ncbi.nlm.nih.gov/pubmed/19289521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01680-08
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