5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages

5-Hydroxymethylcytosine (5hmC) is an important mammalian DNA epigenetic modification that has been linked to gene regulation and cancer pathogenesis. Here we explored the diagnostic potential of 5hmC in circulating cell-free DNA (cfDNA) using a sensitive chemical labeling-based low-input shotgun seq...

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Detalhes bibliográficos
Publicado no:Cell Res
Main Authors: Song, Chun-Xiao, Yin, Senlin, Ma, Li, Wheeler, Amanda, Chen, Yu, Zhang, Yan, Liu, Bin, Xiong, Junjie, Zhang, Weihan, Hu, Jiankun, Zhou, Zongguang, Dong, Biao, Tian, Zhiqi, Jeffrey, Stefanie S, Chua, Mei-Sze, So, Samuel, Li, Weimin, Wei, Yuquan, Diao, Jiajie, Xie, Dan, Quake, Stephen R
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5630676/
https://ncbi.nlm.nih.gov/pubmed/28820176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2017.106
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