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Defining the minimum substrate and charge recognition model of gamma-secretase
γ-Secretase is an intramembrane aspartyl protease that cleaves the C99 fragment of amyloid precursor protein to generate extracellular Aβ peptides. These peptides can oligomerize and aggregate to form amyloid plaques, processes that are widely believed to be causal for Alzheimer's disease. In s...
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| Veröffentlicht in: | Acta Pharmacol Sin |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5630670/ https://ncbi.nlm.nih.gov/pubmed/28414207 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2017.35 |
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