Intermittent treatment with farnesyltransferase inhibitor and sulforaphane improves cellular homeostasis in Hutchinson-Gilford progeria fibroblasts

Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic condition associated with mutations in the LMNA gene. This disease recapitulates some aspects of normal aging, such as hair loss, thin skin, joint stiffness, and atherosclerosis. The latter leads to heart attack or stroke that causes deat...

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Bibliografske podrobnosti
izdano v:Oncotarget
Main Authors: Gabriel, Diana, Shafry, Dinah Dorith, Gordon, Leslie B., Djabali, Karima
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2017
Teme:
Research Paper: Gerotarget (Focus on Aging)
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5630293/
https://ncbi.nlm.nih.gov/pubmed/29029393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.19363
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