Identification of a core TP53 transcriptional program with highly distributed tumor suppressive activity

The tumor suppressor TP53 is the most frequently mutated gene product in human cancer. Close to half of all solid tumors carry inactivating mutations in the TP53 gene, while in the remaining cases, TP53 activity is abrogated by other oncogenic events, such as hyperactivation of its endogenous repres...

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Detalhes bibliográficos
Publicado no:Genome Res
Main Authors: Andrysik, Zdenek, Galbraith, Matthew D., Guarnieri, Anna L., Zaccara, Sara, Sullivan, Kelly D., Pandey, Ahwan, MacBeth, Morgan, Inga, Alberto, Espinosa, Joaquín M.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5630028/
https://ncbi.nlm.nih.gov/pubmed/28904012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.220533.117
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