ΔNp63α Suppresses TGFB2 Expression and RHOA Activity to Drive Cell Proliferation in Squamous Cell Carcinomas

The transcriptional repressor ΔNp63α is a potent oncogene widely overexpressed in squamous cell carcinomas (SCCs) of diverse tissue origins, where it promotes malignant cell proliferation and survival. We report here the results of a genome-wide CRISPR screen to identify pathways controlling ΔNp63α-...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Abraham, Christopher G., Ludwig, Michael P., Andrysik, Zdenek, Pandey, Ahwan, Joshi, Molishree, Galbraith, Matthew D., Sullivan, Kelly D., Espinosa, Joaquin M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6219633/
https://ncbi.nlm.nih.gov/pubmed/30232004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.08.058
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