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Identification of an unexpected shunt pathway product provides new insights into tirandamycin biosynthesis

Tirandamycin K (7), the first linear 7,13;9,13-diseco-tirandamycin derivative, was isolated from the tamI (encoding the TamI P450 monooxygenase) disruption mutant strain (ΔtamI) of marine Streptomyces sp. 307–9. Its chemical structure with relative and absolute configurations was elucidated by a com...

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Bibliografiske detaljer
Udgivet i:Tetrahedron Lett
Main Authors: Zhang, Xingwang, Li, Zhong, Du, Lei, Chlipala, George E., Lopez, Patricia C., Zhang, Wei, Sherman, David H., Li, Shengying
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5628624/
https://ncbi.nlm.nih.gov/pubmed/28989201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2016.11.080
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