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Identification of an unexpected shunt pathway product provides new insights into tirandamycin biosynthesis

Tirandamycin K (7), the first linear 7,13;9,13-diseco-tirandamycin derivative, was isolated from the tamI (encoding the TamI P450 monooxygenase) disruption mutant strain (ΔtamI) of marine Streptomyces sp. 307–9. Its chemical structure with relative and absolute configurations was elucidated by a com...

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Publicat a:Tetrahedron Lett
Autors principals: Zhang, Xingwang, Li, Zhong, Du, Lei, Chlipala, George E., Lopez, Patricia C., Zhang, Wei, Sherman, David H., Li, Shengying
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5628624/
https://ncbi.nlm.nih.gov/pubmed/28989201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2016.11.080
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