Complete elucidation of the late steps of bafilomycin biosynthesis in Streptomyces lohii

Bafilomycins are an important subgroup of polyketides with diverse biological activities and possible applications as specific inhibitors of vacuolar H(+)-ATPase. However, the general toxicity and structural complexity of bafilomycins present formidable challenges to drug design via chemical modific...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Li, Zhong, Du, Lei, Zhang, Wei, Zhang, Xingwang, Jiang, Yuanyuan, Liu, Kun, Men, Ping, Xu, Huifang, Fortman, Jeffrey L., Sherman, David H., Yu, Bing, Gao, Song, Li, Shengying
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409476/
https://ncbi.nlm.nih.gov/pubmed/28292933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.751255
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