Complete elucidation of the late steps of bafilomycin biosynthesis in Streptomyces lohii

Bafilomycins are an important subgroup of polyketides with diverse biological activities and possible applications as specific inhibitors of vacuolar H(+)-ATPase. However, the general toxicity and structural complexity of bafilomycins present formidable challenges to drug design via chemical modific...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Li, Zhong, Du, Lei, Zhang, Wei, Zhang, Xingwang, Jiang, Yuanyuan, Liu, Kun, Men, Ping, Xu, Huifang, Fortman, Jeffrey L., Sherman, David H., Yu, Bing, Gao, Song, Li, Shengying
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2017
Teme:
Microbiology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409476/
https://ncbi.nlm.nih.gov/pubmed/28292933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.751255
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