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Identification of an unexpected shunt pathway product provides new insights into tirandamycin biosynthesis

Tirandamycin K (7), the first linear 7,13;9,13-diseco-tirandamycin derivative, was isolated from the tamI (encoding the TamI P450 monooxygenase) disruption mutant strain (ΔtamI) of marine Streptomyces sp. 307–9. Its chemical structure with relative and absolute configurations was elucidated by a com...

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Detalhes bibliográficos
Publicado no:Tetrahedron Lett
Main Authors: Zhang, Xingwang, Li, Zhong, Du, Lei, Chlipala, George E., Lopez, Patricia C., Zhang, Wei, Sherman, David H., Li, Shengying
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5628624/
https://ncbi.nlm.nih.gov/pubmed/28989201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2016.11.080
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