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A predictive probability design for phase II cancer clinical trials

BACKGROUND: Two- or three-stage designs are commonly used in phase II cancer clinical trials. These designs possess good frequentist properties and allow early termination of the trial when the interim data indicate that the experimental regimen is inefficacious. The rigid study design, however, can...

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Publicado en:Clin Trials
Main Authors: Lee, J. Jack, Liu, Diane D.
Formato: Artigo
Idioma:Inglês
Publicado: 2008
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5626665/
https://ncbi.nlm.nih.gov/pubmed/18375647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1740774508089279
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