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Disease-associated mutations in human BICD2 hyperactivate motility of dynein–dynactin
Bicaudal D2 (BICD2) joins dynein with dynactin into a ternary complex (termed DDB) capable of processive movement. Point mutations in the BICD2 gene have been identified in patients with a dominant form of spinal muscular atrophy, but how these mutations cause disease is unknown. To investigate this...
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| Veröffentlicht in: | J Cell Biol |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Rockefeller University Press
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5626548/ https://ncbi.nlm.nih.gov/pubmed/28883039 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201703201 |
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