The chromatin accessibility signature of human immune aging stems from CD8(+) T cells

Aging is linked to deficiencies in immune responses and increased systemic inflammation. To unravel the regulatory programs behind these changes, we applied systems immunology approaches and profiled chromatin accessibility and the transcriptome in PBMCs and purified monocytes, B cells, and T cells....

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Detaylı Bibliyografya
Yayımlandı:J Exp Med
Asıl Yazarlar: Ucar, Duygu, Márquez, Eladio J., Chung, Cheng-Han, Marches, Radu, Rossi, Robert J., Uyar, Asli, Wu, Te-Chia, George, Joshy, Stitzel, Michael L., Palucka, A. Karolina, Kuchel, George A., Banchereau, Jacques
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Rockefeller University Press 2017
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5626401/
https://ncbi.nlm.nih.gov/pubmed/28904110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20170416
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