The chromatin accessibility signature of human immune aging stems from CD8(+) T cells

Aging is linked to deficiencies in immune responses and increased systemic inflammation. To unravel the regulatory programs behind these changes, we applied systems immunology approaches and profiled chromatin accessibility and the transcriptome in PBMCs and purified monocytes, B cells, and T cells....

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發表在:J Exp Med
Main Authors: Ucar, Duygu, Márquez, Eladio J., Chung, Cheng-Han, Marches, Radu, Rossi, Robert J., Uyar, Asli, Wu, Te-Chia, George, Joshy, Stitzel, Michael L., Palucka, A. Karolina, Kuchel, George A., Banchereau, Jacques
格式: Artigo
語言:Inglês
出版: The Rockefeller University Press 2017
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Research Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5626401/
https://ncbi.nlm.nih.gov/pubmed/28904110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20170416
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