The chromatin accessibility signature of human immune aging stems from CD8(+) T cells

Aging is linked to deficiencies in immune responses and increased systemic inflammation. To unravel the regulatory programs behind these changes, we applied systems immunology approaches and profiled chromatin accessibility and the transcriptome in PBMCs and purified monocytes, B cells, and T cells....

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Bibliografske podrobnosti
izdano v:J Exp Med
Main Authors: Ucar, Duygu, Márquez, Eladio J., Chung, Cheng-Han, Marches, Radu, Rossi, Robert J., Uyar, Asli, Wu, Te-Chia, George, Joshy, Stitzel, Michael L., Palucka, A. Karolina, Kuchel, George A., Banchereau, Jacques
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2017
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5626401/
https://ncbi.nlm.nih.gov/pubmed/28904110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20170416
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