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The chromatin accessibility signature of human immune aging stems from CD8(+) T cells
Aging is linked to deficiencies in immune responses and increased systemic inflammation. To unravel the regulatory programs behind these changes, we applied systems immunology approaches and profiled chromatin accessibility and the transcriptome in PBMCs and purified monocytes, B cells, and T cells....
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| Publicado no: | J Exp Med |
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| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5626401/ https://ncbi.nlm.nih.gov/pubmed/28904110 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20170416 |
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