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The chromatin accessibility signature of human immune aging stems from CD8(+) T cells

Aging is linked to deficiencies in immune responses and increased systemic inflammation. To unravel the regulatory programs behind these changes, we applied systems immunology approaches and profiled chromatin accessibility and the transcriptome in PBMCs and purified monocytes, B cells, and T cells....

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:J Exp Med
Päätekijät: Ucar, Duygu, Márquez, Eladio J., Chung, Cheng-Han, Marches, Radu, Rossi, Robert J., Uyar, Asli, Wu, Te-Chia, George, Joshy, Stitzel, Michael L., Palucka, A. Karolina, Kuchel, George A., Banchereau, Jacques
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The Rockefeller University Press 2017
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5626401/
https://ncbi.nlm.nih.gov/pubmed/28904110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20170416
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