The chromatin accessibility signature of human immune aging stems from CD8(+) T cells

Aging is linked to deficiencies in immune responses and increased systemic inflammation. To unravel the regulatory programs behind these changes, we applied systems immunology approaches and profiled chromatin accessibility and the transcriptome in PBMCs and purified monocytes, B cells, and T cells....

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Exp Med
Prif Awduron: Ucar, Duygu, Márquez, Eladio J., Chung, Cheng-Han, Marches, Radu, Rossi, Robert J., Uyar, Asli, Wu, Te-Chia, George, Joshy, Stitzel, Michael L., Palucka, A. Karolina, Kuchel, George A., Banchereau, Jacques
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Rockefeller University Press 2017
Pynciau:
Research Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5626401/
https://ncbi.nlm.nih.gov/pubmed/28904110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20170416
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