Leukaemia cell of origin identified by chromatin landscape of bulk tumour cells

The precise identity of a tumour's cell of origin can influence disease prognosis and outcome. Methods to reliably define tumour cell of origin from primary, bulk tumour cell samples has been a challenge. Here we use a well-defined model of MLL-rearranged acute myeloid leukaemia (AML) to demons...

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Bibliographic Details
Published in:Nat Commun
Main Authors: George, Joshy, Uyar, Asli, Young, Kira, Kuffler, Lauren, Waldron-Francis, Kaiden, Marquez, Eladio, Ucar, Duygu, Trowbridge, Jennifer J.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4942573/
https://ncbi.nlm.nih.gov/pubmed/27397025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12166
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