Internal deletion of BCOR reveals a tumor suppressor function for BCOR in T lymphocyte malignancies

Recurrent inactivating mutations have been identified in various hematological malignancies in the X-linked BCOR gene encoding BCL6 corepressor (BCOR); however, its tumor suppressor function remains largely uncharacterized. We generated mice missing Bcor exon 4, expressing a variant BCOR lacking the...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Tanaka, Tomoyuki, Nakajima-Takagi, Yaeko, Aoyama, Kazumasa, Tara, Shiro, Oshima, Motohiko, Saraya, Atsunori, Koide, Shuhei, Si, Sha, Manabe, Ichiro, Sanada, Masashi, Nakayama, Manabu, Masuko, Masayoshi, Sone, Hirohito, Koseki, Haruhiko, Iwama, Atsushi
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5626398/
https://ncbi.nlm.nih.gov/pubmed/28827447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20170167
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