Ezh1 Targets Bivalent Genes to Maintain Self-Renewing Stem Cells in Ezh2-Insufficient Myelodysplastic Syndrome

Polycomb repressive complex (PRC) 2 represses transcription through histone H3K27 trimethylation (H3K27me3). We previously reported that the hematopoietic-cell-specific deletion of Ezh2, encoding a PRC2 enzyme, induced myelodysplastic syndrome (MDS) in mice, whereas the concurrent Ezh1 deletion depl...

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Detalhes bibliográficos
Publicado no:iScience
Main Authors: Aoyama, Kazumasa, Oshima, Motohiko, Koide, Shuhei, Suzuki, Emi, Mochizuki-Kashio, Makiko, Kato, Yuko, Tara, Shiro, Shinoda, Daisuke, Hiura, Nobuhiro, Nakajima-Takagi, Yaeko, Sashida, Goro, Iwama, Atsushi
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6223231/
https://ncbi.nlm.nih.gov/pubmed/30396150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2018.10.008
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