Ezh2 loss propagates hypermethylation at T cell differentiation–regulating genes to promote leukemic transformation

Early T cell precursor acute lymphoblastic leukemia (ETP-ALL) is a new pathological entity with poor outcomes in T cell ALL (T-ALL) that is characterized by a high incidence of loss-of-function mutations in polycomb repressive complex 2 (PRC2) genes. We generated a mouse model of ETP-ALL by deleting...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Wang, Changshan, Oshima, Motohiko, Sato, Daisuke, Matsui, Hirotaka, Kubota, Sho, Aoyama, Kazumasa, Nakajima-Takagi, Yaeko, Koide, Shuhei, Matsubayashi, Jun, Mochizuki-Kashio, Makiko, Nakano-Yokomizo, Takako, Bai, Jie, Nagao, Toshitaka, Kanai, Akinori, Iwama, Atsushi, Sashida, Goro
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6118644/
https://ncbi.nlm.nih.gov/pubmed/30080177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI94645
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